ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep—that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.

Encephalopathy with status epilepticus during slow sleep: "the Penelope syndrome".

CANTALUPO, Gaetano;
2009

Abstract

ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep—that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.
ESES; Landau-Kleffner syndrome; CSWS; Cognitive impairment; Behavioral disturbances; Childhood epilepsy; Sleep; Neuroplasticity; Epileptic Encephalopathies; encephalopathy with status epilepticus during sleep; sleep homeostasis; synaptic downscaling
File in questo prodotto:
File Dimensione Formato  
2009 - Tassinari et al. - Penelope Syndrome - Epilepsia.pdf

non disponibili

Licenza: Accesso ristretto
Dimensione 263.56 kB
Formato Adobe PDF
263.56 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/429953
Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 106
  • ???jsp.display-item.citation.isi??? 100
social impact