The intestinal pharmacokinetics of Ciprofloxacin (Cpx) is modified by Itraconazole (Itz), a strong inhibitor of the hepatic metabolism. To better understand the mechanisms involved in the interaction we studied the distribution of Cpx in the gastrointestinal compartment and the expression of the pharmaco-metabolizing system CYP450 and P-gp in the intestine and liver.

Drug interaction: effects of itraconazole on the intestinal pharmaco-metabolising system and ciprofloxacin pharmacokinetics

BERTAZZONI MINELLI, Elisa;BENINI, Anna
2012

Abstract

The intestinal pharmacokinetics of Ciprofloxacin (Cpx) is modified by Itraconazole (Itz), a strong inhibitor of the hepatic metabolism. To better understand the mechanisms involved in the interaction we studied the distribution of Cpx in the gastrointestinal compartment and the expression of the pharmaco-metabolizing system CYP450 and P-gp in the intestine and liver.
Drug interaction, itraconazole, intestinalpharmaco-metabolising system, ciprofloxacin
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/417339
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