Polymethylmethacrylate (PMMA) bone cements are used for the fixation of joint prostheses and for the production of spacers as well as carrier to deliver antibiotics into infection site. We studied the local release of antibiotics from PMMA bone cement nails loaded with a combination of Gentamicin (G) and Vancomycin (V) in an experimental model of osteomyelitis (Methicillin-Resistant S. aureus- MRSA in rabbits) and the correlation with the effect of treatment.

Bone tissue distribution of gentamycin and vancomycin from polymethylmethacrylate intramedullary nails in experimental osteomyelitis model (MRSA infection)

BERTAZZONI MINELLI, Elisa;BENINI, Anna;
2011

Abstract

Polymethylmethacrylate (PMMA) bone cements are used for the fixation of joint prostheses and for the production of spacers as well as carrier to deliver antibiotics into infection site. We studied the local release of antibiotics from PMMA bone cement nails loaded with a combination of Gentamicin (G) and Vancomycin (V) in an experimental model of osteomyelitis (Methicillin-Resistant S. aureus- MRSA in rabbits) and the correlation with the effect of treatment.
PMMA intramedullary nails, antibiotic-loaded cement, gentamicin, vancomycin, joint infection
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/417140
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