Polymethylmethacrylate (PMMA) bone cements are used for the fixation of joint prostheses and for the production of spacers as well as carrier to deliver antibiotics into infection site. We studied the local release of antibiotics from PMMA bone cement nails loaded with a combination of Gentamicin (G) and Vancomycin (V) in an experimental model of osteomyelitis (Methicillin-Resistant S. aureus- MRSA in rabbits) and the correlation with the effect of treatment.
Bone tissue distribution of gentamycin and vancomycin from polymethylmethacrylate intramedullary nails in experimental osteomyelitis model (MRSA infection)
BERTAZZONI MINELLI, Elisa;BENINI, Anna;
2011-01-01
Abstract
Polymethylmethacrylate (PMMA) bone cements are used for the fixation of joint prostheses and for the production of spacers as well as carrier to deliver antibiotics into infection site. We studied the local release of antibiotics from PMMA bone cement nails loaded with a combination of Gentamicin (G) and Vancomycin (V) in an experimental model of osteomyelitis (Methicillin-Resistant S. aureus- MRSA in rabbits) and the correlation with the effect of treatment.
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