"PancPro" as a tool for selecting families eligible for pancreatic cancer screening: An Italian study of incident cases.

Leonardi, G.; Marchi, S.; Falconi, Massimo; Zerbi, A.; Ussia, V.; Bortoli, N. d.; Mosca, F.; Presciuttini, S.; Chiaro, M. D.

doi:10.1016/j.dld.2011.12.019

CATALOGO DEI PRODOTTI DELLA RICERCA

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BACKGROUND: PancPRO is a computer program that estimates the risk of pancreatic cancer for asymptomatic individuals based on a genetic model of susceptibility and the familial incidence of cancer. AIM: To evaluate the distribution of the familial risk in a series of incident cases of pancreatic adenocarcinoma. MATERIALS AND METHODS: The lifetime risk of pancreatic cancer was calculated by PancPro for a hypothetical 40-year-old son of 570 consecutive probands with pancreatic cancer. RESULTS: The 570 risk values were included between 1\% and 13\%. The distribution was bimodal, with the antimode located at risk=7.5\%. Considering a 10-fold risk over the general population as a threshold for including a subject in a surveillance program, 19 families (3.3\%) would be selected, totalling 92 first-degree relatives with age >40 years. CONCLUSIONS: PancPro is a valid instrument to rank families based on risk of pancreatic cancer.

Titolo:	"PancPro" as a tool for selecting families eligible for pancreatic cancer screening: An Italian study of incident cases.
Autori:	G. Leonardi S. Marchi FALCONI, Massimo A. Zerbi V. Ussia N. d. Bortoli F. Mosca S. Presciuttini M. D. Chiaro mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2012
Rivista:	DIGESTIVE AND LIVER DISEASE
Abstract:	BACKGROUND: PancPRO is a computer program that estimates the risk of pancreatic cancer for asymptomatic individuals based on a genetic model of susceptibility and the familial incidence of cancer. AIM: To evaluate the distribution of the familial risk in a series of incident cases of pancreatic adenocarcinoma. MATERIALS AND METHODS: The lifetime risk of pancreatic cancer was calculated by PancPro for a hypothetical 40-year-old son of 570 consecutive probands with pancreatic cancer. RESULTS: The 570 risk values were included between 1\% and 13\%. The distribution was bimodal, with the antimode located at risk=7.5\%. Considering a 10-fold risk over the general population as a threshold for including a subject in a surveillance program, 19 families (3.3\%) would be selected, totalling 92 first-degree relatives with age >40 years. CONCLUSIONS: PancPro is a valid instrument to rank families based on risk of pancreatic cancer.
Handle:	http://hdl.handle.net/11562/410539
Appare nelle tipologie:	01.01 Articolo in Rivista

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