Insulin resistance and the associated hyperinsulinemia are thought to play a primary role in the metabolic, endocrine and reproductive abnormalities of women with polycystic ovary syndrome (PCOS). Treatment of PCOS includes lifestyle interventions and use of several drugs, in particular oral contraceptives, antiandrogens, metformin and clomiphene citrate. Although live birth rate is not improved by metformin, this insulin sensitising agent, which has a favourable safety profile and may be used long term, induces resumption of ovulation and attenuation of metabolic alterations in many of these women. These characteristics give metformin, usually combined with lifestyle changes, a unique role in the management of PCOS.
For what reasons should metformin be used in the management of PCOS?
MOGHETTI, Paolo
2012-01-01
Abstract
Insulin resistance and the associated hyperinsulinemia are thought to play a primary role in the metabolic, endocrine and reproductive abnormalities of women with polycystic ovary syndrome (PCOS). Treatment of PCOS includes lifestyle interventions and use of several drugs, in particular oral contraceptives, antiandrogens, metformin and clomiphene citrate. Although live birth rate is not improved by metformin, this insulin sensitising agent, which has a favourable safety profile and may be used long term, induces resumption of ovulation and attenuation of metabolic alterations in many of these women. These characteristics give metformin, usually combined with lifestyle changes, a unique role in the management of PCOS.
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