Reversible Pisa syndrome in patients with Parkinson's disease on rasagiline therapy.

We report 4 PD patients who presented reversible PS induced by rasagiline treatment, introduced to manage mild motor worsening or wearing-off phenomena. Within 4 weeks after rasagiline 1 mg/day introduction, the patients developed PS. Withdrawal of rasagiline led to the rapid improvement of posture within 4 weeks in all cases confirmed by EMG testing in longissimus thoracis muscle. The recognition of reversibility of PS during the initial stages of its appearance may be of considerable clinical importance as it may facilitate the rapid withdrawal or reintroduction of dopaminergic treatment.