While the effects of short-term benzodiazepine treatment have been extensively studied in several well-designed, controlled, clinical trials, further information is needed on the value and risks of anxiolytic drugs when administered over months to maintain chronic patients. Clinical trials on the effects of long-term benzodiazepine treatment present several methodological problems. The aim of this paper is to discuss these problems in relation to samples, drugs and dosage, duration, measures and experimental design.
The long-term treatment with benzodiazepines: suggestions for further research
ZIMMERMANN, Christa
1980-01-01
Abstract
While the effects of short-term benzodiazepine treatment have been extensively studied in several well-designed, controlled, clinical trials, further information is needed on the value and risks of anxiolytic drugs when administered over months to maintain chronic patients. Clinical trials on the effects of long-term benzodiazepine treatment present several methodological problems. The aim of this paper is to discuss these problems in relation to samples, drugs and dosage, duration, measures and experimental design.
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