OBJECTIVE: The aim of this study was to develop and compare two DXA-based four-compartment [body weight=body cell mass (BCM)+extracellular fluid (ECF)+extracellular solids (ECS)+fat] cellular level models. RESEARCH METHODS AND PROCEDURES: Total body potassium (TBK) model: BCM from TBK by whole-body counting-ECF(TBK)=LST-[BCM(TBK)+0.73 x osseous mineral (Mo)]. Bromide model: ECF from sodium bromide dilution-BCM(BROMIDE)=LST-(ECF(BROMIDE)+0.73xMo); Mo and LST measurements came from DXA. The two approaches were evaluated in 99 healthy men and 118 women. RESULTS: BCM estimates were highly correlated (r=0.97, p<0.001), as were ECF estimates (r=0.87, p<0.001); a small statistically significant mean difference was present (mean+/-SD; BCM(TBK) model, 30.4+/-8.9 kg; BCM(BROMIDE), 31.4+/-9.3 kg; Delta=1.0+/-2.8 kg; p<0.001; ECF(TBK), 18.5+/-4.2 kg; ECF(BROMIDE), 17.5+/-3.6 kg; Delta=1.0+/-2.8 kg; p<0.001). A high correlation (r=0.97, p<0.001) and good agreement (38.9+/-9.5 vs. 38.9+/-9.5 kg; Delta=0.0+/-2.4 kg; p=0.39) were present between TBW, derived as the sum of intracellular water from TBK and ECW from bromide, and measured TBW by 2H2O dilution. DISCUSSION: Two developed four-compartment cellular level DXA models, one of which is appropriate for use in most clinical and research settings, provide comparable results and are applicable for BCM and ECF estimation of subject groups with hydration disturbances

Four-compartment cellular level body composition model: comparison of two approaches.

Pietrobelli, Angelo;
2005

Abstract

OBJECTIVE: The aim of this study was to develop and compare two DXA-based four-compartment [body weight=body cell mass (BCM)+extracellular fluid (ECF)+extracellular solids (ECS)+fat] cellular level models. RESEARCH METHODS AND PROCEDURES: Total body potassium (TBK) model: BCM from TBK by whole-body counting-ECF(TBK)=LST-[BCM(TBK)+0.73 x osseous mineral (Mo)]. Bromide model: ECF from sodium bromide dilution-BCM(BROMIDE)=LST-(ECF(BROMIDE)+0.73xMo); Mo and LST measurements came from DXA. The two approaches were evaluated in 99 healthy men and 118 women. RESULTS: BCM estimates were highly correlated (r=0.97, p<0.001), as were ECF estimates (r=0.87, p<0.001); a small statistically significant mean difference was present (mean+/-SD; BCM(TBK) model, 30.4+/-8.9 kg; BCM(BROMIDE), 31.4+/-9.3 kg; Delta=1.0+/-2.8 kg; p<0.001; ECF(TBK), 18.5+/-4.2 kg; ECF(BROMIDE), 17.5+/-3.6 kg; Delta=1.0+/-2.8 kg; p<0.001). A high correlation (r=0.97, p<0.001) and good agreement (38.9+/-9.5 vs. 38.9+/-9.5 kg; Delta=0.0+/-2.4 kg; p=0.39) were present between TBW, derived as the sum of intracellular water from TBK and ECW from bromide, and measured TBW by 2H2O dilution. DISCUSSION: Two developed four-compartment cellular level DXA models, one of which is appropriate for use in most clinical and research settings, provide comparable results and are applicable for BCM and ECF estimation of subject groups with hydration disturbances
body compartments; measurements; adults; body mass; DXA; extracellular fluid; intracellular fluid; body potassium
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/364020
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact