Broad spectrum neutralizing antibodies against HIV-1 are essential for the development of a humoral anti-AIDS vaccine. We used fusion complexes and CD4-independent gp120 as new immunogens to induce neutralizing antibodies blocking the infectivity of different primary isolates of HIV-1.
Fusion complexes and CD4-independent Env for the induction of broad spectrum neutralizing antibodies against HIV-1
ASTONE, Dalila;ROSSOLILLO, Paola;MATUCCI, Andrea;RACCHIOLLI, Pierpaolo;ZIPETO, Donato
2011-01-01
Abstract
Broad spectrum neutralizing antibodies against HIV-1 are essential for the development of a humoral anti-AIDS vaccine. We used fusion complexes and CD4-independent gp120 as new immunogens to induce neutralizing antibodies blocking the infectivity of different primary isolates of HIV-1.
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