The uninterrupted generation throughout life of the dentate gyrus [DGY] granule cells [GCs] (one site of adult neurogenesis), which initiate the encoding of novel memories, is driven by signals from the DGy GC precursors tiny, non-motile primary cilia. The hypothesis is surmised that the damage of such primary cilia be responsible of the crippling decline of memory formation in Alzheimer's Disease [AD]. Were human DGy CGs ciliated like their rodent counterparts, part of the AD cases might be indeed based upon a ciliopathy.

Is Alzheimer’s Disease at Least Partly a Ciliopathy?

ARMATO, Ubaldo;CHIARINI, Anna Maria;DAL PRÀ, Ilaria Pierpaola;
2011

Abstract

The uninterrupted generation throughout life of the dentate gyrus [DGY] granule cells [GCs] (one site of adult neurogenesis), which initiate the encoding of novel memories, is driven by signals from the DGy GC precursors tiny, non-motile primary cilia. The hypothesis is surmised that the damage of such primary cilia be responsible of the crippling decline of memory formation in Alzheimer's Disease [AD]. Were human DGy CGs ciliated like their rodent counterparts, part of the AD cases might be indeed based upon a ciliopathy.
Amyloid-β peptide; Alzheimer’s Disease; Dentate Gyrus; Entorhinal Cortex; Granule Cell; Primary Cilium
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/363209
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