A meta-analysis of the published literature was performed in order to quantify the efficacy of low-dose neuroleptic therapy in reducing extrapyramidal side effects in schizophrenic patients. A low-dose regimen between 50-100 mg equivalents of chlorpromazine, in comparison to a standard-dose regimen between 200-500 mg reduced extrapyramidal side effects by a 0.30 (+/-0.12) standard deviation, which is only a limited effect.

Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: An effect size analysis.

BARBUI, Corrado;
1996-01-01

Abstract

A meta-analysis of the published literature was performed in order to quantify the efficacy of low-dose neuroleptic therapy in reducing extrapyramidal side effects in schizophrenic patients. A low-dose regimen between 50-100 mg equivalents of chlorpromazine, in comparison to a standard-dose regimen between 200-500 mg reduced extrapyramidal side effects by a 0.30 (+/-0.12) standard deviation, which is only a limited effect.
neuroleptic therapy; side effects; schizophrenia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/362940
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