Interaction of large granular lymphocytes with susceptible target does not induce second messenger and cytolytic granule exocytosis.

Pollis, F.; Rosato, A.; Bronte, Vincenzo; Mandruzzato, S.; Zambon, A.; Zambello, R.; Pizzo, P.; Zanovello, P.

We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.

Titolo:	Interaction of large granular lymphocytes with susceptible target does not induce second messenger and cytolytic granule exocytosis.
Autori:	F. Pollis A. Rosato Bronte, Vincenzo S. Mandruzzato A. Zambon R. Zambello P. Pizzo P. Zanovello mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1992
Rivista:	LEUKEMIA
Abstract:	We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.
Handle:	http://hdl.handle.net/11562/360031
Appare nelle tipologie:	01.01 Articolo in Rivista

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http://hdl.handle.net/11562/360031

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