This is the first study to compare lymphocyte subsets of UCB with that of PBL of related mothers. Some differences to previous studies comparing UCB lymphocyte subsets with healthy unrelated adults may be explained by this fact. Genetic kinship should play a significant role in lymphocyte function that routinely cytomics usually could not outline. This issue claims for the need that UCB should be compared to related mothers’ APB in order to address further insights on UCB lymphocyte distribution and immune physiology in newborns.
Lymphocyte phenotypic subsets in umbilical cord blood compared to peripheral blood from related mothers
CHIRUMBOLO, Salvatore;ORTOLANI, RICCARDO;VENERI, DINO;RAFFAELLI, Ricciarda;Peroni, Diego;PIGOZZI, Roberta;COLOMBATTI, Marco;VELLA, ANTONIO
2011-01-01
Abstract
This is the first study to compare lymphocyte subsets of UCB with that of PBL of related mothers. Some differences to previous studies comparing UCB lymphocyte subsets with healthy unrelated adults may be explained by this fact. Genetic kinship should play a significant role in lymphocyte function that routinely cytomics usually could not outline. This issue claims for the need that UCB should be compared to related mothers’ APB in order to address further insights on UCB lymphocyte distribution and immune physiology in newborns.
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