Asthma in childhood is characterized by chronic infl ammation. Measurement ofbioimpedance (BI) is a non-invasive way of detecting airway infl ammation. The aim was to compareBI with exhaled nitric oxide (eNO) and lung function evaluations in asthmatic allergic childrenwhile not exposed to offending allergens.Methods: 22 asthmatic children allergic to house dust mites have been enrolled while residentsat high altitude in an environment free of house dust mites. They were evaluated at T0 afterallergen exposure at home, at T1 and at T2 after 1 and 4 months of allergen avoidance, respectively.Results: eNO decreased from 32.21 ± 5.70 ppb at T0 to 21.92 ± 4.36 ppb at T1, after one monthat high altitude (p = 0.038), without a further decrease at T2. Data in electrical activity showeda signifi cant decrease in conductivity of lower airways between T0 (48.53 ± 3.53 A) and T1(42.08 ± 3.47 A) (p = 0.023). B parameter (difference between conductivity of lower respiratorytract and average yield) showed signifi cant decrease from T0 (20.75 ± 2.64 A), and T1(12.84 ± 2.52 A) (p < 0.01), but no further decrease at T2. No difference in lung function parameterswas observed.Conclusion: Allergen avoidance regimen modifi es infl ammatory parameters in allergic asthmatics.Evaluation of extracellular bioelectrical conductivity seems to represent a promisingnon-invasive method to assess airway infl ammation

Bioimpedance monitoring of airway inflammation in asthmatic allergic children.

Peroni, Diego;BODINI, Alessandro;TENERO, Laura;PIACENTINI, Giorgio
2009-01-01

Abstract

Asthma in childhood is characterized by chronic infl ammation. Measurement ofbioimpedance (BI) is a non-invasive way of detecting airway infl ammation. The aim was to compareBI with exhaled nitric oxide (eNO) and lung function evaluations in asthmatic allergic childrenwhile not exposed to offending allergens.Methods: 22 asthmatic children allergic to house dust mites have been enrolled while residentsat high altitude in an environment free of house dust mites. They were evaluated at T0 afterallergen exposure at home, at T1 and at T2 after 1 and 4 months of allergen avoidance, respectively.Results: eNO decreased from 32.21 ± 5.70 ppb at T0 to 21.92 ± 4.36 ppb at T1, after one monthat high altitude (p = 0.038), without a further decrease at T2. Data in electrical activity showeda signifi cant decrease in conductivity of lower airways between T0 (48.53 ± 3.53 A) and T1(42.08 ± 3.47 A) (p = 0.023). B parameter (difference between conductivity of lower respiratorytract and average yield) showed signifi cant decrease from T0 (20.75 ± 2.64 A), and T1(12.84 ± 2.52 A) (p < 0.01), but no further decrease at T2. No difference in lung function parameterswas observed.Conclusion: Allergen avoidance regimen modifi es infl ammatory parameters in allergic asthmatics.Evaluation of extracellular bioelectrical conductivity seems to represent a promisingnon-invasive method to assess airway infl ammation
2009
Asthma; Inflammation; Children; Extracellular electrical impedancetomography; Bioimpedance; Exhaled nitric oxide; Allergen avoidance
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/355604
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