Case discussion of an immediate serious reaction to hexavalent vaccine mistaken for anaphylaxis

Anaphylaxis is rarely associated with vaccination. Clinicalpresentation may include a variety of non-specific symptoms, making a clinical diagnosis uncertain. Therefore, it isimportant to distinguish anaphylaxis from other adverseevents following immunization (AEFIs), particularly in children, to manage subsequent immunizations where necessary. For administration of additional doses a specialistevaluation is recommended to confirm the diagnosis andconsider if re-vaccination is appropriate. A post-eventevaluation is based on an in-depth history and skin and invitro testing to identify specific sensitizations. Applying astandardized AEFI case definition, such as the Brighton Collaboration, is also helpful for individual cases as well aspharmacovigilance activities