The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia.To replicate this association in an independent population with a different genetic background.The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland.It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95\% CI 1.14 to 1.52).These data provide further evidence of the association of MS disease with variation within CBLB.
Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population.
BENEDETTI, MARIADONATA;
2011-01-01
Abstract
The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia.To replicate this association in an independent population with a different genetic background.The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland.It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95\% CI 1.14 to 1.52).These data provide further evidence of the association of MS disease with variation within CBLB.
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