The rise in the prescribing of antidepressants is largely accounted for by an increase in long term treatment. Half of people with a diagnosis of major depression will go on to have a further episode, and risk of recurrence increases with each episode. Evidence for the benefits of long term prescribing of antidepressants comes almost exclusively from secondary care settings. Continuing antidepressant treatment roughly halves the absolute risk of relapse The increased risk of suicidal behaviour associated with selective serotonin reuptake inhibitors (SSRIs) is restricted to people aged under 25 People with risk factors for relapse of depression should be advised to continue with SSRIs for at least 12 months and consider long term treatment.

Long term treatment of depression with selective serotonin reuptake inhibitors and newer antidepressants

BARBUI, Corrado
2010-01-01

Abstract

The rise in the prescribing of antidepressants is largely accounted for by an increase in long term treatment. Half of people with a diagnosis of major depression will go on to have a further episode, and risk of recurrence increases with each episode. Evidence for the benefits of long term prescribing of antidepressants comes almost exclusively from secondary care settings. Continuing antidepressant treatment roughly halves the absolute risk of relapse The increased risk of suicidal behaviour associated with selective serotonin reuptake inhibitors (SSRIs) is restricted to people aged under 25 People with risk factors for relapse of depression should be advised to continue with SSRIs for at least 12 months and consider long term treatment.
2010
Antidepressive Agents/therapeutic use; Cardiovascular Diseases/chemically induced; Depressive Disorder/drug therapy; Female; Hemorrhage/chemically induced; Humans; Hyponatremia/chemically induced; Long-Term Care; Medication Adherence; Pregnancy; Pregnancy Complications/etiology; Recurrence/prevention & control; Risk Factors; Self-Injurious Behavior/psychology; Serotonin Uptake Inhibitors/therapeutic use; Sexual Dysfunction; Physiological/chemically induced Suicide/psychology
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/341346
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