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EnglishThe BCR signalling pathway is therapeutically promising, and recent data indicate that it might be important in the pathogenesis of B-CLL and DLBCL. Its importance in MCL was suggested by gene expression studies. We show that tonic BCR signalling might be one of the mechanisms driving cell survival and proliferation in MCL, and that the inhibition of SYK might be a viable therapeutic approach. More studies are needed to verify the importance in vivo of this pathway.
| Titolo: | Phospho-tyrosine profiling of mantle cell lymphoma cells suggests the BCR signalling pathwayn as a potential therapeutic target |
| Autori: | |
| Data di pubblicazione: | 2009 |
| Rivista: | |
| Abstract: | The BCR signalling pathway is therapeutically promising, and recent data indicate that it might be important in the pathogenesis of B-CLL and DLBCL. Its importance in MCL was suggested by gene expression studies. We show that tonic BCR signalling might be one of the mechanisms driving cell survival and proliferation in MCL, and that the inhibition of SYK might be a viable therapeutic approach. More studies are needed to verify the importance in vivo of this pathway. |
| Handle: | http://hdl.handle.net/11562/335533 |
| Appare nelle tipologie: | 04.02 Abstract in Atti di convegno |
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| File | Descrizione | Tipologia | Licenza | |
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| Virchows Archiv 2009, 455 252 - Copia 252.pdf | Documento in Post-print | Accesso ristretto | Administrator Richiedi una copia |
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