Purpose: To investigate changes in urinary PGE<sub>2</sub> after ibuprofen treatment in preterm infants with patent ductus arteriosus (PDA). Methods: Twenty preterm infants with a hemodynamically significant PDA (gestational age, 28.6∈±∈2.3 weeks) and 20 controls (gestational age, 30.4∈±∈1.5 weeks) were prospectively enrolled at 48-72 h of life. After enrollment, the former underwent conventional ibuprofen-lysine treatment. At 48-72 h (T<sub>0</sub>) and 108-144 h of life (T<sub>1</sub>), urine samples were noninvasively collected in both groups to measure urinary PGE<sub>2</sub> concentrations (enzyme immunoassay method), and renal function was investigated. Results: Urinary PGE<sub>2</sub> decreased significantly both in ibuprofen-treated patients (66.95∈±∈16.78 vs. 27.15∈±∈17.92 pg/mL, P∈<∈0.001) and in controls (71.7∈±∈16.2 vs. 53.2∈±∈18.4 pg/mL, P∈<∈0.001) from T<sub>0</sub> to T<sub>1</sub>. However, urinary PGE<sub>2</sub> at T<sub>1</sub> was significantly lower (P∈<∈0. 001) in the ibuprofen group compared to the control group. Acute renal failure occurred in three ibuprofen-treated patients (15%). Conclusions: Ibuprofen markedly reduces (59.4%) urinary PGE<sub>2</sub> and may alter renal function in the newborn.
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