Background/Aims: Non-alcoholic fatty liver disease (NAFLD) and chronic plaque psoriasis are both associated with the metabolic syndrome and increased risk of incident cardiovascular disease. We assessed the frequency and characteristics of NAFLD in patients with chronic plaque psoriasis. Methods: 130 consecutive patients with chronic plaque psoriasis and 260 apparently healthy controls matched for age, sex and body mass index were enrolled. NAFLD was diagnosed by abdominal ultrasound after excluding other secondary causes of chronic liver disease. Results: The frequency of NAFLD was remarkably greater in psoriasis patients than in controls (47% vs. 28%; p<0.0001). Patients with psoriasis and NAFLD (n=61) were more likely to have the metabolic syndrome, and had significantly higher serum C-reactive protein and interleukin-6 levels, and lower serum adiponectin than those with psoriasis alone (n=69). They also had greater severity of psoriasis according to the Psoriasis Area and Severity Index (PASI) score (14.2 ± 12.6 vs. 9.6 ± 7.4; p<0.01). In multivariate regression analysis, NAFLD was associated with higher PASI score independently of age, gender, body mass index, psoriasis duration, and alcohol consumption. Conclusions: NAFLD is frequent in patients with chronic plaque psoriasis - affecting up to nearly half of these patients - and is strongly associated with psoriasis severity. Early recognition of NAFLD in this group of patients is very important for better management.

Nonalcoholic fatty liver disease in patients with chronic plaque psoriasis.

GISONDI, Paolo;TARGHER, Giovanni;ZOPPINI, Giacomo;GIROLOMONI, Giampiero
2009

Abstract

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) and chronic plaque psoriasis are both associated with the metabolic syndrome and increased risk of incident cardiovascular disease. We assessed the frequency and characteristics of NAFLD in patients with chronic plaque psoriasis. Methods: 130 consecutive patients with chronic plaque psoriasis and 260 apparently healthy controls matched for age, sex and body mass index were enrolled. NAFLD was diagnosed by abdominal ultrasound after excluding other secondary causes of chronic liver disease. Results: The frequency of NAFLD was remarkably greater in psoriasis patients than in controls (47% vs. 28%; p<0.0001). Patients with psoriasis and NAFLD (n=61) were more likely to have the metabolic syndrome, and had significantly higher serum C-reactive protein and interleukin-6 levels, and lower serum adiponectin than those with psoriasis alone (n=69). They also had greater severity of psoriasis according to the Psoriasis Area and Severity Index (PASI) score (14.2 ± 12.6 vs. 9.6 ± 7.4; p<0.01). In multivariate regression analysis, NAFLD was associated with higher PASI score independently of age, gender, body mass index, psoriasis duration, and alcohol consumption. Conclusions: NAFLD is frequent in patients with chronic plaque psoriasis - affecting up to nearly half of these patients - and is strongly associated with psoriasis severity. Early recognition of NAFLD in this group of patients is very important for better management.
Nonalcoholic fatty liver disease; psoriasis; metabolic syndrome
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/328857
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