An efficient new stereocontrolled synthesis of (2R,6R)-(+)- and (2S,6S)-(-)-2,6-diamino-4-methylene-1,7-heptanedioic acid 8a and 9a, respectively, has been accomplished starting from the glycine-derived chiral synthon 1. The enantiomerically pure alpha-alkyl derivatives 8b-d and 9b-d have also been synthesized. The absolute configuration of the new stereocenters was assigned on the basis of H-1 NMR spectra
Stereocontrolled synthesis of enantiomerically pure unsaturated analogues of 2,6-DAP. Part 5
PICCINELLI, FABIO;
2003-01-01
Abstract
An efficient new stereocontrolled synthesis of (2R,6R)-(+)- and (2S,6S)-(-)-2,6-diamino-4-methylene-1,7-heptanedioic acid 8a and 9a, respectively, has been accomplished starting from the glycine-derived chiral synthon 1. The enantiomerically pure alpha-alkyl derivatives 8b-d and 9b-d have also been synthesized. The absolute configuration of the new stereocenters was assigned on the basis of H-1 NMR spectra
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