Non steoidal anti-inflammatory drugs induce cardiovascular adverse events, and this appears to be a function of intensity and duration of treatment, irrespectively of their selectivity towards cyclo-oxygenase 2. Deteminants are the degree of inhibiton in prostacyclin synthesis and the residual capacity to synthesize thromboxane in platelets.
Titolo: | Nonsteroidal anti-inflammatory drugs and cardiovascular risk: is prostacyclin inhibition the key event? |
Autori: | |
Data di pubblicazione: | 2008 |
Rivista: | |
Abstract: | Non steoidal anti-inflammatory drugs induce cardiovascular adverse events, and this appears to be a function of intensity and duration of treatment, irrespectively of their selectivity towards cyclo-oxygenase 2. Deteminants are the degree of inhibiton in prostacyclin synthesis and the residual capacity to synthesize thromboxane in platelets. |
Handle: | http://hdl.handle.net/11562/323679 |
Appare nelle tipologie: | 01.01 Articolo in Rivista |
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