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|Titolo:||Two different dosages of yeast derived recombinant hepatitis B vaccines: A comparison of immunogenicity|
|Autori interni:||MAJORI, Silvia|
MOSCHEN, Maria Elisa
|Data di pubblicazione:||1996|
|Abstract:||The efficacy of a 10 or 20 mu-g antigen load of HB recombinant vaccines is still being debated. A comparison of anti-HBs titres in two groups of healthy subjects vaccinated by the same schedule (0, 1 and 6 months) employing recombinant HB vaccines with different antigen loads, 20 mu-g (group A, 251 subjects) and 10 mu-g (group B, 256 subjects) was carried out. A seroprotection rate of 99.6 and 99.2% was observed for group A and group B, respectively, at the end of primary immunization. No statistically significant difference in seroprotection rate was observed. Group A showed significantly higher GMTs than group B for all age groups and for both sexes except for males above 25 years. The difference was more marked for younger age groups and for the female sex. These data support the higher immunogenicity of vaccine with 20 mu-g antigen load as compared to vaccines with 10 mu-g antigen load.|
|Appare nelle tipologie:||01.01 Articolo in Rivista|
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