Objective To evaluate the association between.-glutamyl transferase (GGT) and homocysteine in plasma. Methods Combined results of GGT, total homocysteine, vitamin B12, folate and creatinine levels were analyzed in outpatients referred for laboratory testing over the past 5 years. Results Cumulative results for homocysteine, GGT, B12, creatinine, folate could be retrieved for 449 outpatients > 35 years old over the study period. The concentration of homocysteine significantly increased among tertiles of GGT activity. In multivariable linear regression analysis, GGT activity was independently associated with homocysteine concentration, independent of age, gender, folate, vitamin B12 and serum creatinine levels. Discussion Plasma GGT activity might be a useful means to predict homocysteine concentration in the general population.
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