We tested fluoxetine, bupropion and GR 205171, a selective neurokinin-1 receptor antagonist on forced swimming test (FST) response and on levels of monoamines in frontal cortex of CD1 mice by microdialysis techniques. All drugs decreased immobility time. Fluoxetine augmented all monoamines, bupropion enhanced catecholamines, and GR 205171 was totally ineffective. Results suggest that FST response may not be related to levels of monoamines in the mouse frontal cortex

Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the responce in the forced swim test and on monoamine extracellulars levels in the frontal cortex of the mouse.

ZANETTI, LARA;
2003-01-01

Abstract

We tested fluoxetine, bupropion and GR 205171, a selective neurokinin-1 receptor antagonist on forced swimming test (FST) response and on levels of monoamines in frontal cortex of CD1 mice by microdialysis techniques. All drugs decreased immobility time. Fluoxetine augmented all monoamines, bupropion enhanced catecholamines, and GR 205171 was totally ineffective. Results suggest that FST response may not be related to levels of monoamines in the mouse frontal cortex
Microdialysis; Antidepressants; Brain monoamines; Forced swim test; Mouse
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/313248
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