INTRODUCTION: The combination of TGE sequences with bolus injection of paramagnetic contrast agents permits to study renal function and perfusion. We studied renal function with both an ionic (Gd-DTPA) and a nonionic paramagnetic contrast agent (Gd-DTPA-BMA) to compare their kinetics in normal kidneys. MATERIAL AND METHODS: Twenty MR examinations were performed on 20 subjects with normal renal function. Ten subjects were examined after i.v. injection of Gd-DTPA and the other ten subjects after i.v. injection of Gd-DTPA-BMA. MR examinations were performed on a Philips ACS II unit (1.5 T). Two sequences were acquired in all cases; an SE coronal T1-weighted sequence (TR/TE = 600/19 ms) and a TGE coronal T1-weighted sequence (TR/TE = 12/5 ms, flip angle = 25 degrees) performed after bolus injection of the contrast agent at 0.1 mmol/kg. Signal intensity time curves were obtained in all the cases. The signal intensity of the cortex, corticomedullary junction, medulla and the pyelocaliceal system of each kidney was measured using a region of interest (ROI). Signal intensity curves were analyzed considering some quantitative parameters such as the area under the curve (AUC), the peak (P) and the time to peak (T-P). RESULTS: In the subjects with normal renal function, four phases were demonstrated after the i.v. injection of either Gd-DTPA or Gd-DTPA-BMA, namely the cortical phase, the cortico-medullary junction phase, the medullary phase and the pyelocaliceal system phase. No statistically significant differences between the two agents were demonstrated in signal intensity time curves and quantitative parameters. CONCLUSIONS: Gd-DTPA and Gd-DTPA-BMA showed the same efficacy in renal function studies.
A comparison between an ionic paramagnetic contrast agent (Gd-DTPA) and a nonionic one (Gd-DTPA-BMA) in functional kidney evaluation with magnetic resonance
POZZI MUCELLI, Roberto;
1997-01-01
Abstract
INTRODUCTION: The combination of TGE sequences with bolus injection of paramagnetic contrast agents permits to study renal function and perfusion. We studied renal function with both an ionic (Gd-DTPA) and a nonionic paramagnetic contrast agent (Gd-DTPA-BMA) to compare their kinetics in normal kidneys. MATERIAL AND METHODS: Twenty MR examinations were performed on 20 subjects with normal renal function. Ten subjects were examined after i.v. injection of Gd-DTPA and the other ten subjects after i.v. injection of Gd-DTPA-BMA. MR examinations were performed on a Philips ACS II unit (1.5 T). Two sequences were acquired in all cases; an SE coronal T1-weighted sequence (TR/TE = 600/19 ms) and a TGE coronal T1-weighted sequence (TR/TE = 12/5 ms, flip angle = 25 degrees) performed after bolus injection of the contrast agent at 0.1 mmol/kg. Signal intensity time curves were obtained in all the cases. The signal intensity of the cortex, corticomedullary junction, medulla and the pyelocaliceal system of each kidney was measured using a region of interest (ROI). Signal intensity curves were analyzed considering some quantitative parameters such as the area under the curve (AUC), the peak (P) and the time to peak (T-P). RESULTS: In the subjects with normal renal function, four phases were demonstrated after the i.v. injection of either Gd-DTPA or Gd-DTPA-BMA, namely the cortical phase, the cortico-medullary junction phase, the medullary phase and the pyelocaliceal system phase. No statistically significant differences between the two agents were demonstrated in signal intensity time curves and quantitative parameters. CONCLUSIONS: Gd-DTPA and Gd-DTPA-BMA showed the same efficacy in renal function studies.
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