Cyclooxygenase-2 (COX-2) is extensively expressed in multiple sclerosis lesions suggesting that regulatory variants of the COX-2 gene could be implicated in multiple sclerosis (MS). Screening of the proximal 5' regulatory region and genotyping of -765G>C and -62C>G showed that polymorphisms in this COX-2 region are unlikely to be involved in MS susceptibility.
COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G>C with disease risk
MAZZOLA, Silvia
;GOMEZ, Maria Macarena;BENEDETTI, MARIADONATA;SALVIATI, Alessandro;MALERBA, Giovanni;PIGNATTI, Pierfranco
2007-01-01
Abstract
Cyclooxygenase-2 (COX-2) is extensively expressed in multiple sclerosis lesions suggesting that regulatory variants of the COX-2 gene could be implicated in multiple sclerosis (MS). Screening of the proximal 5' regulatory region and genotyping of -765G>C and -62C>G showed that polymorphisms in this COX-2 region are unlikely to be involved in MS susceptibility.
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