The HIV-1 viral envelope originates from the cell membrane and contains different cellular proteins such as MHC class I molecules, which play a role in modulating viral infectivity. HLA-C is known to enhance viral infectiv- ity and reduce sensitivity to neutralizing antibodies by inducing gp120/41 conformational changes that may increase fusion efficiency and viral infectivity [1]. In this work we studied the effect of HLA-C on syncytia forma- tion and of its association with the HIV-1 gp120/41 and with the CD4/CCR5 receptors in purified fusion com- plexes.
HLA-C increases fusion efficiency between the HIV-1 envelope and the cell membrane and is part of the fusion complex
MATUCCI, Andrea;ROSSOLILLO, Paola;BERTAZZONI, Umberto;ZIPETO, Donato
2006-01-01
Abstract
The HIV-1 viral envelope originates from the cell membrane and contains different cellular proteins such as MHC class I molecules, which play a role in modulating viral infectivity. HLA-C is known to enhance viral infectiv- ity and reduce sensitivity to neutralizing antibodies by inducing gp120/41 conformational changes that may increase fusion efficiency and viral infectivity [1]. In this work we studied the effect of HLA-C on syncytia forma- tion and of its association with the HIV-1 gp120/41 and with the CD4/CCR5 receptors in purified fusion com- plexes.
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