The aim was to explore whether the origin of carbohydrate oxidation (exogenous compared with endogenous carbohydrate) after consumption of a mixed meal was influenced by obesity in children. Ten obese prepubertal children 8 y of age (44.2 ± 3.6 kg) were studied over 9.5 h and compared with eight normal-weight, matched control children (28.5 ± 1.6 kg). They were fed a mixed meal containing naturally enriched [ 13C]carbohydrate (cane sugar and popcorn) providing 55% of the daily energy requirement as measured by 24-h resting metabolic rate. Total carbohydrate oxidation was calculated by indirect calorimetry (hood system) whereas exogenous carbohydrate oxidation was estimated from carbon dioxide production (V̇CO 2), the isotopic enrichment of breath 13CO 2, and the abundance of [ 13C]carbohydrate in the meal ingested. The time course of 13CO 2 in breath-measured over 570 min-followed a similar pattern in both groups. Although total carbohydrate oxidation was not significantly different among the two groups, exogenous carbohydrate utilization was significantly greater (P < 0.03) and endogenous carbohydrate oxidation was significantly lower (P < 0.05) in obese compared with control children. In addition, the rate of exogenous carbohydrate oxidation expressed as a proportion of total carbohydrate oxidation was positively related to the body fat of the children (r = 0.68, P < 0.01). The study suggests that in the postprandial phase, a smaller proportion of carbohydrate oxidation is accounted for by glycogen breakdown in obese children. The sparing or endogenous glycogen may result from decreased glycogen turnover already present at an early age.
Total and exogenous carbohydrate oxidation in obese prepubertal children.
MAFFEIS, Claudio;ZAFFANELLO, Marco;
1996-01-01
Abstract
The aim was to explore whether the origin of carbohydrate oxidation (exogenous compared with endogenous carbohydrate) after consumption of a mixed meal was influenced by obesity in children. Ten obese prepubertal children 8 y of age (44.2 ± 3.6 kg) were studied over 9.5 h and compared with eight normal-weight, matched control children (28.5 ± 1.6 kg). They were fed a mixed meal containing naturally enriched [ 13C]carbohydrate (cane sugar and popcorn) providing 55% of the daily energy requirement as measured by 24-h resting metabolic rate. Total carbohydrate oxidation was calculated by indirect calorimetry (hood system) whereas exogenous carbohydrate oxidation was estimated from carbon dioxide production (V̇CO 2), the isotopic enrichment of breath 13CO 2, and the abundance of [ 13C]carbohydrate in the meal ingested. The time course of 13CO 2 in breath-measured over 570 min-followed a similar pattern in both groups. Although total carbohydrate oxidation was not significantly different among the two groups, exogenous carbohydrate utilization was significantly greater (P < 0.03) and endogenous carbohydrate oxidation was significantly lower (P < 0.05) in obese compared with control children. In addition, the rate of exogenous carbohydrate oxidation expressed as a proportion of total carbohydrate oxidation was positively related to the body fat of the children (r = 0.68, P < 0.01). The study suggests that in the postprandial phase, a smaller proportion of carbohydrate oxidation is accounted for by glycogen breakdown in obese children. The sparing or endogenous glycogen may result from decreased glycogen turnover already present at an early age.
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