Trimers of bovine pancreatic RNase A were obtained by cross-linking native RNase A with dimethyl suberimidate. They degrade double-stranded RNA more efficiently than dimers and monomers of RNase A, and display significant cytotoxic and/or cytostatic actions against C4-I cells (a human cell line derived from squamous carcinoma of the uterus cervix). On the same cell line cross-linked dimers of RNase A appear to be ineffective.
|Titolo:||Cross-linked trimers of bovine ribonuclease A: activity on double-stranded RNA and antitumor action|
LIBONATI, Massimo (Corresponding)
|Data di pubblicazione:||1997|
|Appare nelle tipologie:||01.01 Articolo in Rivista|