Trimers of bovine pancreatic RNase A were obtained by cross-linking native RNase A with dimethyl suberimidate. They degrade double-stranded RNA more efficiently than dimers and monomers of RNase A, and display significant cytotoxic and/or cytostatic actions against C4-I cells (a human cell line derived from squamous carcinoma of the uterus cervix). On the same cell line cross-linked dimers of RNase A appear to be ineffective.
Titolo: | Cross-linked trimers of bovine ribonuclease A: activity on double-stranded RNA and antitumor action |
Autori: | LIBONATI, Massimo (Corresponding) |
Data di pubblicazione: | 1997 |
Rivista: | |
Handle: | http://hdl.handle.net/11562/307124 |
Appare nelle tipologie: | 01.01 Articolo in Rivista |
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.