OBJECTIVES:To evaluate the predictive role of primary tumor histopathological features in predicting inguinal lymph nodes involvement in patients with penile squamous cell carcinoma.MATERIAL AND METHODS:We retrospectively analysed pathological records from 30 consecutive patients who underwent penectomy for invasive squamous cell carcinoma of the penis. All histological specimens were reviewed by the same pathologist. We considered the following histological parameters: histological grading, growth pattern, deph invasion, tumour thickness, nuclear grading, poorly differentiated cancer rate, vascular and lymphatic embolization, eosinophilic and mononuclear infiltration and pathological stage.RESULTS:Lymph nodes involvement occurred in 5 patients who underwent 'early' lymphadenectomy and in other 4 ones during oncological surveillance. Lymph nodes metastasis resulted significantly correlated with histological grading (p = 0.005), lymphatic (p = 0.005) and venous (p = 0.02) embolization, corpora cavernosa (p = 0.03) and urethra (p = 0.03) infiltration. Histological grading and lymphatic embolization were independent predictive variables of lymph nodes involvement (p = 0.02).CONCLUSIONS:The histological grading and lymphatic embolization have to be considered as important parameters to select patients with penile squamous cell carcinoma to undergo an 'early' lymphadenectomy.

Predictive pathological factors of lymph nodes involvement in the squamous cell carcinoma of the penis

MARTIGNONI, Guido;CERRUTO, Maria Angela;ARTIBANI, Walter
2002-01-01

Abstract

OBJECTIVES:To evaluate the predictive role of primary tumor histopathological features in predicting inguinal lymph nodes involvement in patients with penile squamous cell carcinoma.MATERIAL AND METHODS:We retrospectively analysed pathological records from 30 consecutive patients who underwent penectomy for invasive squamous cell carcinoma of the penis. All histological specimens were reviewed by the same pathologist. We considered the following histological parameters: histological grading, growth pattern, deph invasion, tumour thickness, nuclear grading, poorly differentiated cancer rate, vascular and lymphatic embolization, eosinophilic and mononuclear infiltration and pathological stage.RESULTS:Lymph nodes involvement occurred in 5 patients who underwent 'early' lymphadenectomy and in other 4 ones during oncological surveillance. Lymph nodes metastasis resulted significantly correlated with histological grading (p = 0.005), lymphatic (p = 0.005) and venous (p = 0.02) embolization, corpora cavernosa (p = 0.03) and urethra (p = 0.03) infiltration. Histological grading and lymphatic embolization were independent predictive variables of lymph nodes involvement (p = 0.02).CONCLUSIONS:The histological grading and lymphatic embolization have to be considered as important parameters to select patients with penile squamous cell carcinoma to undergo an 'early' lymphadenectomy.
2002
Penile squamous cell carcinoma, Histopathological features, Lymph nodes involvement, Inguinal lymphadenectomy.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/307042
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 36
  • ???jsp.display-item.citation.isi??? ND
social impact