The in-vitro activity of MEN 10700, a novel penem, was compared with that of imipenem, ritipenem, ampicillin/sulbactam, cefotaxime, ciprofloxacin and amikacin against 1088 strains taken from 21 genera, including Gram-negative, Gram-positive and anaerobic bacteria. MIC data showed that MEN 10700 was very active against staphylococci and streptococci (MICinf 9inf 0 <= 0.5 mg/L) and against most members of the Enterobacteriaceae (MICinf 9inf 0 <= 2 mg/L), with reduced activity only against Providencia stuartii (MICinf 9inf 0 = 8 mg/L). MEN 10700 was also active against anaerobic species such as Clostridium perfringens and Bacteroides fragilis as well as Moraxella catarrhalis. It was moderately active against Enterococcus faecalis and inactive against Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Aeromonas spp. and Acinetobacter spp. Its antibacterial spectrum was thus slightly narrower than that of imipenem, but compared favourably with those of a third-generation cephalosporin and ritipenem. MEN 107

MEN 10700, a new penem antibiotic: In-vitro activity and its correlation with beta-lactamase stability, PBP affinity and diffusion through the bacterial cell wall

FONTANA, Roberta;MAZZARIOL, Annarita;CORNAGLIA, Giuseppe
1998-01-01

Abstract

The in-vitro activity of MEN 10700, a novel penem, was compared with that of imipenem, ritipenem, ampicillin/sulbactam, cefotaxime, ciprofloxacin and amikacin against 1088 strains taken from 21 genera, including Gram-negative, Gram-positive and anaerobic bacteria. MIC data showed that MEN 10700 was very active against staphylococci and streptococci (MICinf 9inf 0 <= 0.5 mg/L) and against most members of the Enterobacteriaceae (MICinf 9inf 0 <= 2 mg/L), with reduced activity only against Providencia stuartii (MICinf 9inf 0 = 8 mg/L). MEN 10700 was also active against anaerobic species such as Clostridium perfringens and Bacteroides fragilis as well as Moraxella catarrhalis. It was moderately active against Enterococcus faecalis and inactive against Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Aeromonas spp. and Acinetobacter spp. Its antibacterial spectrum was thus slightly narrower than that of imipenem, but compared favourably with those of a third-generation cephalosporin and ritipenem. MEN 107
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/306303
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