It has been described that the onset of lymphomas may be linked to some infections or chronic immune stimulation. Data concerning the prevalence of hepatitis C virus (HCV) infection in B-cell malignancies are not univocal. On the other hand, the association between monoclonal gammopathies and HCV infection has been clearly shown only for mixed cryoglobulinemia. Less clear is the HCV prevalence in other conditions, such as IgM type-monoclonal gammopathy of uncertain significance (MGUS) or Waldenström’s macroglobulinemia (WM). All these studies were characterized by a small number of patients, which prevented the Authors from coming to any definitive conclusions. Consequently, we have tried to answer this question by analyzing the HCV prevalence in a larger number of IgM type-MGUS and MW patients we followed over a period of more than ten years.

Prevalence of hepatitis C virus infection in IgM-type monoclonal gammopathy of uncertain significance and Waldenstrom macroglobulinemia.

KRAMPERA, Mauro
2004-01-01

Abstract

It has been described that the onset of lymphomas may be linked to some infections or chronic immune stimulation. Data concerning the prevalence of hepatitis C virus (HCV) infection in B-cell malignancies are not univocal. On the other hand, the association between monoclonal gammopathies and HCV infection has been clearly shown only for mixed cryoglobulinemia. Less clear is the HCV prevalence in other conditions, such as IgM type-monoclonal gammopathy of uncertain significance (MGUS) or Waldenström’s macroglobulinemia (WM). All these studies were characterized by a small number of patients, which prevented the Authors from coming to any definitive conclusions. Consequently, we have tried to answer this question by analyzing the HCV prevalence in a larger number of IgM type-MGUS and MW patients we followed over a period of more than ten years.
IgM monoclonal gammopathy; chronic hepatitis C
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/305110
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 7
social impact