Diagnosis of PA requires confirmation by a specific inhibitory challenge; in our series of inhibition tests, PA diagnosis was confirmed by the CL-based assay in only 1 of 10 patients with RIA-diagnosed PA. When we used the RIA results as the reference interval, the CL assay failed to confirm PA in 90% of cases, thus showing very low specificity. Our data demonstrate that use of the CL assay without validation by an RIA method might lead to undiagnosed PA in a large number of patients.
Plasma Aldosterone assay: comparison between chemiluminescence and radioimmunologic methods
PIZZOLO, Francesca;GUARINI, Patrizia;CORROCHER, Roberto;OLIVIERI, Oliviero
2006-01-01
Abstract
Diagnosis of PA requires confirmation by a specific inhibitory challenge; in our series of inhibition tests, PA diagnosis was confirmed by the CL-based assay in only 1 of 10 patients with RIA-diagnosed PA. When we used the RIA results as the reference interval, the CL assay failed to confirm PA in 90% of cases, thus showing very low specificity. Our data demonstrate that use of the CL assay without validation by an RIA method might lead to undiagnosed PA in a large number of patients.
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