This multicentric study concerns the post-operative evolution of patients operated obstetrically or gynaecologically receiving seaprose S or nimesulide treatment. One hundred and three patients were enrolled in the study. Their mean age was 40,9±11,6 (S.D.). Fifty patients were treated with seaprose S tablets (30 mg t.i.d.) and the other 53 patients with nimesulide tablets (100 mg b.i.d.) for 14 days. Clinical assessment involved a thorough examination of the surgical wound daily to the 7th day and, thereafter, on the 14th day (end of treatment) and the 28th day (follow-up). An examination of the results revealed that both treatments are effective and produce positive control of inflammation and pain present post-operatively. There was one case of mild gastric pyrosis with seaprose S and, with nimesulide, one case of severe vomiting and a mild case of epigastralgia. It may be concluded that seaprose S, a proteolytic enzyme with marked antioedemic and secretolytic activity, is a valid therapeutic alternative in obstetric and gynaecologic complications.
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