The authors describe 12 neuroleptic-treated patients with dementia of various etiologies who showed CSF elevation of phosphorylated 14-3-3zeta and normal tau protein levels. This contrasted with elevated amounts of 14-3-3 gamma, epsilon, and unphosphorylated zeta coupled to high tau protein levels in Creutzfeldt-Jakob disease and negative 14-3-3 assay in drug-free patients with dementia. Characterization of CSF 14-3-3 isoforms and determination of tau protein level can help to distinguish different etiologies of dementia can help to distinguish different etiologies of dementia.
Phosphorylated 14-3-3zeta protein in the CSF of neuroleptic-treated patients
ZANUSSO, Gianluigi;FIORINI, Michele;FARINAZZO, Alessia;GELATI, Matteo;BENEDETTI, MARIADONATA;FERRARI, Sergio;CAPALDI, Stefano;MONACO, Ugo Luigi;RIZZUTO, Nicolo';MONACO, Salvatore
2005-01-01
Abstract
The authors describe 12 neuroleptic-treated patients with dementia of various etiologies who showed CSF elevation of phosphorylated 14-3-3zeta and normal tau protein levels. This contrasted with elevated amounts of 14-3-3 gamma, epsilon, and unphosphorylated zeta coupled to high tau protein levels in Creutzfeldt-Jakob disease and negative 14-3-3 assay in drug-free patients with dementia. Characterization of CSF 14-3-3 isoforms and determination of tau protein level can help to distinguish different etiologies of dementia can help to distinguish different etiologies of dementia.
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