Histochemical, electron microscopy and biochemical studies were performed on muscle biopsy specimens from 11 AIDS patients treated with zidovudine. A peculiar association of structural abnormalities and mitochondrial dysfunction was found. Focal cytochrome c oxidase (COX) deficiency was evident in muscle sections from 9 patients, 8 of whom had received long-term treatment while one had been treated for 1 month only. Electron microscopy showed changes in number, size and structure of mitochondria. Biochemical studies proved partial COX and succinate cytochrome c reductase (SCR) deficiency in 4 patients; one patient had only reduced SCR activity. Our data confirm that AZT therapy can cause toxic myopathy with mitochondrial dysfunction.

AZT-induced mitochondrial myopathy

TOMELLERI, Giuliano;TONIN, PAOLA;BONETTI, Bruno;MONACO, Salvatore;SALVIATI, Alessandro;RIZZUTO, Nicolo'
1992

Abstract

Histochemical, electron microscopy and biochemical studies were performed on muscle biopsy specimens from 11 AIDS patients treated with zidovudine. A peculiar association of structural abnormalities and mitochondrial dysfunction was found. Focal cytochrome c oxidase (COX) deficiency was evident in muscle sections from 9 patients, 8 of whom had received long-term treatment while one had been treated for 1 month only. Electron microscopy showed changes in number, size and structure of mitochondria. Biochemical studies proved partial COX and succinate cytochrome c reductase (SCR) deficiency in 4 patients; one patient had only reduced SCR activity. Our data confirm that AZT therapy can cause toxic myopathy with mitochondrial dysfunction.
AIDS; AZT; cytochrome c oxidase; mitochondrial myopathy; succinate cytochrome c reductase; type 2 fiber atrophy;
AIDS; AZT; mitochondrial myopathy; cytochrome c oxidase; succinate cytochrome c reductase; type 2 fiber atrophy
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/304490
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 28
social impact