The persistence of minimal residual disease (MRD) following the induction of complete remission (CR) in patients with acute lymphoblastic leukemia (ALL) predicts a poor outcome in childhood, whereas fewer data are so far available in adults. In the present study we investigated MRD in a single center series of 24 adult patients with ALL using a flowcytometric approach based on the detection of leukemia-specific marker combinations.
Flow-cytometric detection of minimal residual disease in adult acute lymphoblastic leukemia
KRAMPERA, Mauro;PERBELLINI, Omar;PIZZOLO, Giovanni
2001-01-01
Abstract
The persistence of minimal residual disease (MRD) following the induction of complete remission (CR) in patients with acute lymphoblastic leukemia (ALL) predicts a poor outcome in childhood, whereas fewer data are so far available in adults. In the present study we investigated MRD in a single center series of 24 adult patients with ALL using a flowcytometric approach based on the detection of leukemia-specific marker combinations.
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