The past decade has been characterized by growing interest in the idea that atherosclerosis is an inflammatory disease. Interaction of the multipotent immunomodulator CD40 ligand (CD40L) with its receptor CD40 has emerged as an important contributor to the inflammatory processes that lead to atherosclerosis and thrombosis. At present, little is known regarding the impact of the diabetic state itself on sCD40L levels, particularly in type 1 diabetic patients. The evidence from this and other studies (4) supports the hypothesis that the increase of sCD40L levels in type 1 diabetic patients can, at least in part, be explained by the presence of clinical micro- and macrovascular complications, smoking, or other traditional coronary risk factors. Interpretation of our results, however, requires care because of the relatively small number of patients. Future studies using larger cohorts will be needed to validate this hypothesis.

Soluble CD40L in young type 1 diabetic individuals without clinical microvascular and macrovascular complications.

TARGHER, Giovanni;ZOPPINI, Giacomo
2004-01-01

Abstract

The past decade has been characterized by growing interest in the idea that atherosclerosis is an inflammatory disease. Interaction of the multipotent immunomodulator CD40 ligand (CD40L) with its receptor CD40 has emerged as an important contributor to the inflammatory processes that lead to atherosclerosis and thrombosis. At present, little is known regarding the impact of the diabetic state itself on sCD40L levels, particularly in type 1 diabetic patients. The evidence from this and other studies (4) supports the hypothesis that the increase of sCD40L levels in type 1 diabetic patients can, at least in part, be explained by the presence of clinical micro- and macrovascular complications, smoking, or other traditional coronary risk factors. Interpretation of our results, however, requires care because of the relatively small number of patients. Future studies using larger cohorts will be needed to validate this hypothesis.
CD40L; type 1 diabetes; atherosclerosis; coronary risk factors
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/304249
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