AimsTo examine the association of non-alcoholic hepatic steatosis (HS) withthe activity of the hypothalamo-pituitary-adrenal (HPA) axis in Type 2 diabeticindividuals.MethodsThe activity of the HPA axis, as measured by 24-h urinary free cortisol(UFC) excretion and serum cortisol levels after 1.0 mg dexamethasone, wasmeasured in 40 diet-controlled, predominantly overweight, Type 2 diabeticpatients with non-alcoholic HS and in 40 diabetic patients without HS whowere comparable for age, sex and body mass index (BMI).ResultsSubjects with non-alcoholic HS had significantly higher 24-h UFCexcretion (191±4 vs. 102±3 nmol/24 h;P< 0.001) and post-dexamethasonecortisol concentrations (29.1±2 vs. 14.4±1 nmol/ l;P< 0.001) than thosewithout HS. Patients with HS had significantly higher values for HOMA insulinresistance score, plasma triglycerides and liver enzymes. Age, sex, BMI, waist–hip ratio (WHR), diabetes duration, HbA1c, LDL-cholesterol and blood pressurevalues were not different between the groups. The differences in urinaryand serum cortisol concentrations between the groups remained significant afteradjustment for age, sex, BMI, WHR, HOMA insulin resistance score, plasmatriglycerides, HbA1cand liver enzymes. In multiple logistic regression analyses,24-h UFC or serum cortisol concentrations (P <0.05 andP= 0.02, respectively),along with age and HOMA insulin resistance, predicted the presence of HS,independently of potential confounders.ConclusionsThese results demonstrate that non-alcoholic HS is closely associatedwith a subtle, chronic overactivity of the HPA axis in diet-controlled Type 2diabetic individuals.

Relationship of nonalcoholic hepatic steatosis to cortisol secretion in diet-controlled type 2 diabetic patients.

TARGHER, Giovanni;ZOPPINI, Giacomo;FALEZZA, Giancarlo
2005-01-01

Abstract

AimsTo examine the association of non-alcoholic hepatic steatosis (HS) withthe activity of the hypothalamo-pituitary-adrenal (HPA) axis in Type 2 diabeticindividuals.MethodsThe activity of the HPA axis, as measured by 24-h urinary free cortisol(UFC) excretion and serum cortisol levels after 1.0 mg dexamethasone, wasmeasured in 40 diet-controlled, predominantly overweight, Type 2 diabeticpatients with non-alcoholic HS and in 40 diabetic patients without HS whowere comparable for age, sex and body mass index (BMI).ResultsSubjects with non-alcoholic HS had significantly higher 24-h UFCexcretion (191±4 vs. 102±3 nmol/24 h;P< 0.001) and post-dexamethasonecortisol concentrations (29.1±2 vs. 14.4±1 nmol/ l;P< 0.001) than thosewithout HS. Patients with HS had significantly higher values for HOMA insulinresistance score, plasma triglycerides and liver enzymes. Age, sex, BMI, waist–hip ratio (WHR), diabetes duration, HbA1c, LDL-cholesterol and blood pressurevalues were not different between the groups. The differences in urinaryand serum cortisol concentrations between the groups remained significant afteradjustment for age, sex, BMI, WHR, HOMA insulin resistance score, plasmatriglycerides, HbA1cand liver enzymes. In multiple logistic regression analyses,24-h UFC or serum cortisol concentrations (P <0.05 andP= 0.02, respectively),along with age and HOMA insulin resistance, predicted the presence of HS,independently of potential confounders.ConclusionsThese results demonstrate that non-alcoholic HS is closely associatedwith a subtle, chronic overactivity of the HPA axis in diet-controlled Type 2diabetic individuals.
NAFLD; cortisol; type 2 diabetes
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/304246
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