In 633 consecutive patients with monoclonal gammopathy of undetermined significance (MGUS) the probability of malignant evolution was 9, 17 and 51% at 5, 10 and 15 years, respectively, after diagnosis. The values of monoclonal component, Bence-Jones proteinuria and erythrocyte sedimentation rate were associated with malignant transformation.
Malignant evolution of monoclonal gammopathy of undetermined significance: analysis of 633 consecutive cases with a long term follow-up.
KRAMPERA, Mauro;PIZZOLO, Giovanni
2004-01-01
Abstract
In 633 consecutive patients with monoclonal gammopathy of undetermined significance (MGUS) the probability of malignant evolution was 9, 17 and 51% at 5, 10 and 15 years, respectively, after diagnosis. The values of monoclonal component, Bence-Jones proteinuria and erythrocyte sedimentation rate were associated with malignant transformation.
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