BACKGROUND:Certain medications may contribute to the etiology of depressive symptoms and disorders. Research in this area, however, has been hampered by methodological and conceptual problems. This review had two objectives: to identify evidence linking medical drugs to depressive symptoms and disorders, and to summarize this evidence in a clinically meaningful way.METHODS:Electronic literature searches were performed and studies were reviewed with reference to critical methodological features.RESULTS:No medications causing the typical major depressive syndrome were identified. Evidence was found linking corticosteroids, interferon-alpha, interleukin-2, gonadotropin-releasing hormone agonists, mefloquine, progestin-releasing implanted contraceptives and propranolol to the etiology of atypical depressive syndromes.CONCLUSIONS:A small number of drugs have been shown capable of inducing depressive symptoms. Drug-induced depression appears to differ symptomatically from classical major depression.

Drug-induced depression. A systematic review to inform clinical practice

Barbui C.
2004-01-01

Abstract

BACKGROUND:Certain medications may contribute to the etiology of depressive symptoms and disorders. Research in this area, however, has been hampered by methodological and conceptual problems. This review had two objectives: to identify evidence linking medical drugs to depressive symptoms and disorders, and to summarize this evidence in a clinically meaningful way.METHODS:Electronic literature searches were performed and studies were reviewed with reference to critical methodological features.RESULTS:No medications causing the typical major depressive syndrome were identified. Evidence was found linking corticosteroids, interferon-alpha, interleukin-2, gonadotropin-releasing hormone agonists, mefloquine, progestin-releasing implanted contraceptives and propranolol to the etiology of atypical depressive syndromes.CONCLUSIONS:A small number of drugs have been shown capable of inducing depressive symptoms. Drug-induced depression appears to differ symptomatically from classical major depression.
2004
Depressive disorder, chemically induced; Drug-induced depression; Organic depression; Substance-induced mood disorder;
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/303905
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