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|Titolo:||Identification by monoclonal antibodies of a new epitope in the glycoprotein complex of Sindbis virus|
|Autori interni:||LIBOI, Elio Maria|
|Data di pubblicazione:||1983|
|Rivista:||JOURNAL OF VIROLOGICAL METHODS|
|Abstract:||Monoclonal antibodies against a deletion mutant of Sindbis virus were produced and characterized in order to determine the fine mapping and functional activities of single viral epitopes. All monoclonal antibodies so far tested showed a certain degree of reciprocal competition and were directed against an antigenic determinant which was present only on the undissociated complex of the E1 and E2 glycoproteins. A biological assay measuring viral haemagglutination showed no decrease in the titre of viral samples preincubated with monoclonal antibodies. Conversely, a reduction in viral infectivity was demonstrated, particularly with two of these antibodies. The results suggest that the antibodies which we characterized seem to recognize a new epitope which is represented on both glycoproteins on the surface of this mutant of Sindbis virus.|
|Appare nelle tipologie:||01.01 Articolo in Rivista|
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