Synapse elimination is a widespread developmental process in the peripheral and central nervous system that brings about refinement of neural connections through epigenetic mechanisms. Here we describe recent advances concerning the role of the pattern of motoneuronal firing, synchronous or asynchronous, in neuromuscular synapse elimination.
Activity-dependent synaptic competition at mammalian neuromuscular junctions
BUFFELLI, Mario Rosario;BUSETTO, Giuseppe;FAVERO, Morgana;CANGIANO, Alberto
2004-01-01
Abstract
Synapse elimination is a widespread developmental process in the peripheral and central nervous system that brings about refinement of neural connections through epigenetic mechanisms. Here we describe recent advances concerning the role of the pattern of motoneuronal firing, synchronous or asynchronous, in neuromuscular synapse elimination.
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