Osteoporosis and osteopenia are frequent complications of thalassemiamajor (TM) and intermedia (TI). Osteoporosis was found in 23/25 patientswith TI and in 115/239 patients with TM. In TM, no association wasfound with specific polymorphisms in candidate genes (vitamin D receptor, estrogenreceptor, calcitonin receptor, and collagen type 1 alpha 1). Osteoporosisin female patients with TM was strongly associated with primary amenorrhea(P < .0001), while in male patients with TM, hypogonadism was not significantlyrelated to bone mineral density (BMD) (P = .0001). Low BMD was also associatedwith cardiomiopathy (P = .01), diabetes mellitus (P = .0001), chronichepatitis (P = .0029), and increased ALT (P = .01).
|Titolo:||osteoporosis in (beta) - Thalassemia: Clinical and Genetic Aspect|
|Data di pubblicazione:||2005|
|Appare nelle tipologie:||01.01 Articolo in Rivista|