Lipoprotein(a) (Lp(a)) is a genetic variant of low density lipoproteins and consists of the covalent association of the unique and enigmatic apolipoprotein(a) to apoliprotein B100. Despite the high degree of homology with low density lipoproteins, Lp(a) displays distinctive physicochemical properties, function and metabolism. The present article reviews the main biological and clinical evidences about the association between raised concentration of Lp(a) and athero-thrombotic diseases and provides tentative guidelines to improve the clinical usefulness of Lp(a) measurements.
Biochemical risk factors and patient's outcome: the case of lipoprotein(a)
Lippi G.;Guidi G.
1999-01-01
Abstract
Lipoprotein(a) (Lp(a)) is a genetic variant of low density lipoproteins and consists of the covalent association of the unique and enigmatic apolipoprotein(a) to apoliprotein B100. Despite the high degree of homology with low density lipoproteins, Lp(a) displays distinctive physicochemical properties, function and metabolism. The present article reviews the main biological and clinical evidences about the association between raised concentration of Lp(a) and athero-thrombotic diseases and provides tentative guidelines to improve the clinical usefulness of Lp(a) measurements.
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