The 14-3-3 protein, a cerebrospinal fluid (CSF) marker of neuronal damage that was recently adopted for the diagnosis of Creutzfeldt-Jakob disease, is also found in the CSF of patients with a variety of neurological disorders. We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. All patients who recovered cleared 14-3-3 protein from the CSF before discharge from the hospital (this was the first CSF marker to clear), whereas those who died never cleared the protein.

Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis.

ZANUSSO, Gianluigi;MONACO, Salvatore;FERRARI, Sergio;RIZZUTO, Nicolo';CONCIA, Ercole;
2003

Abstract

The 14-3-3 protein, a cerebrospinal fluid (CSF) marker of neuronal damage that was recently adopted for the diagnosis of Creutzfeldt-Jakob disease, is also found in the CSF of patients with a variety of neurological disorders. We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. All patients who recovered cleared 14-3-3 protein from the CSF before discharge from the hospital (this was the first CSF marker to clear), whereas those who died never cleared the protein.
14-3-3 protein; clearance; Creutzfeldt-Jakob disease; diagnosis; purulent bacterial meningitis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/26622
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