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|Titolo:||Etude par chromatografie d'affinite' de la variation chez l'homme pendant une surcharge sodee de l'inhibiteur endogene de la Na-K-ATPase [Affinity chromatographic study of the changes in the endogenous Na+-K+-ATPase inhibitor during sodium loading in man]|
|Autori interni:||DELVA, Pietro|
|Data di pubblicazione:||1984|
|Rivista:||ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX|
|Abstract:||Semi-purified dog kidney Na+-K+-ATPase was cross-linked with ovalbumin. This immobilized enzyme was able to hydrolyse ATP and this hydrolysis was ouabain-sensitive. It was then used in batch wise affinity chromatography for the detection of endogenous Na+-K+-ATPase inhibitor in human plasma and urine. Ammonium acetate 1 mM washed off the endogenous Na+-K+-ATPase inhibitor from the immobilized enzyme. The inhibitory activity of the eluate from hypertensive plasma was significantly higher (p less than 0.0025, n = 6) than that of normotensive plasma. Similar results were obtained (n = 3) from human urine eluates during salt loading as compared to control urine.|
|Appare nelle tipologie:||01.01 Articolo in Rivista|
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