In RA, synovial CD30+ cells would be part of the Th2‐type response acting as a homeostatic mechanism to counterbalance the proinflammatory events driven by Th1‐type cells/cytokines. They would exert their anti‐inflammatory activity through the synergistic action of IL‐4 and IL‐10. The possibility of evaluating such activity by simply measuring the levels of circulating sCD30, in all phases of the disease (relapse, remission) and in response to therapy, may offer better insight into the mechanisms involved in controlling disease evolution.
Unmasking the anti-inflammatory cytochine response in rheumatoid synovitis
LUNARDI, Claudio;
2002-01-01
Abstract
In RA, synovial CD30+ cells would be part of the Th2‐type response acting as a homeostatic mechanism to counterbalance the proinflammatory events driven by Th1‐type cells/cytokines. They would exert their anti‐inflammatory activity through the synergistic action of IL‐4 and IL‐10. The possibility of evaluating such activity by simply measuring the levels of circulating sCD30, in all phases of the disease (relapse, remission) and in response to therapy, may offer better insight into the mechanisms involved in controlling disease evolution.
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