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EnglishThe narrow spectrum of HIV-specific neutralizing anti- bodies points to the need for new immunogens based on highly conserved epitopes. HIV-1 infects host cells by membrane fusion: during this process conserved epitopes are exposed on the viral glycoprotein gp120/41 that may be used as targets for the induction of antibodies against HIV-1. Neutralizing antibodies against different heterolo- gous HIV-1 isolates may be obtained by immunizing mice with fusion complexes on which conserved epitopes have been stabilized by fixation, or with gp120/41s with a CD4-independent phenotype on which these conserved epitopes may be already exposed.
| Titolo: | Fusion complexes and CD4-independent gp120s for the induction of HIV-1 neutralizing antibodies |
| Autori: | |
| Data di pubblicazione: | 2005 |
| Rivista: | |
| Abstract: | The narrow spectrum of HIV-specific neutralizing anti- bodies points to the need for new immunogens based on highly conserved epitopes. HIV-1 infects host cells by membrane fusion: during this process conserved epitopes are exposed on the viral glycoprotein gp120/41 that may be used as targets for the induction of antibodies against HIV-1. Neutralizing antibodies against different heterolo- gous HIV-1 isolates may be obtained by immunizing mice with fusion complexes on which conserved epitopes have been stabilized by fixation, or with gp120/41s with a CD4-independent phenotype on which these conserved epitopes may be already exposed. |
| Handle: | http://hdl.handle.net/11562/236864 |
| Appare nelle tipologie: | 01.01 Articolo in Rivista |
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